Advances in the field chronobiology have potential implications for physical as well as mental health and human behavior. Several paradigm-shifting discoveries established key mechanistic principles for the biological clock. We trace the origins and key discoveries that helped to advance the field of chronobiology and a ground-breaking work recently recognized by Nobel prize. https://www.roneverhart.com/New-Orleans-Po-Boy-Fest-Maple-Leaf-Bar-3x3/