Abstract Rad51 maintains genome integrity. whereas Rad52 causes non-canonical homologous recombination leading to gross chromosomal rearrangements (GCRs). Here we find that fission yeast Srr1/Ber1 and Skb1/PRMT5 promote GCRs at centromeres. Genetic and physical analyses show that srr1 and skb1 mutations reduce isochromosome formation mediated by centromere inverted repeats. https://www.roneverhart.com/Brown-Paper-Luncheon-Napkin-Live-Joyfully-13-x-13-500-count-box/